The IGFBP 7 homolog Imp - L 2 promotes insulin signaling 1 in distinct neurons of the Drosophila brain
نویسنده
چکیده
3 R. Bader, L. Sarraf-Zadeh, M. Peters, N. Moderau, H. Stocker, K. Köhler, M. J. 4 Pankratz, E. Hafen 5 1. LIMES Life and Medical Sciences, Laboratory of Molecular Brain Physiology and 6 Behavior, University of Bonn, Bonn 53115, Germany 7 2. Institute for Molecular Systems Biology (IMSB), ETH Zurich, Zurich 8093, 8 Switzerland 9 3. These authors contributed equally to this work 10 4. Co-corresponding authors 11 12 Correspondence to: 13 Ernst Hafen, Phone: +41 44 633 36 88; Fax: +41 44 633 11 41 14 E-Mail: [email protected] 15 16 Michael J. Pankratz, Phone: +44 228 7362740; Fax: +44 228 7362641 17 E-Mail: [email protected] 18 19 20 21 22 23 24 25 © 2013. Published by The Company of Biologists Ltd.
منابع مشابه
The IGFBP7 homolog Imp-L2 promotes insulin signaling in distinct neurons of the Drosophila brain.
In Drosophila, Insulin-like peptide 2 (Dilp-2) is expressed by insulin-producing cells in the brain, and is secreted into the hemolymph to activate insulin signaling systemically. Within the brain, however, a more local activation of insulin signaling may be required to couple behavioral and physiological traits to nutritional inputs. We show that a small subset of neurons in the larval brain h...
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